Our lab is focused on understanding the etiology of craniofacial phenotypes by combining deep phenotyping and genomics. Our primary phenotype of interest are orofacial clefts, the most common craniofacial anomaly in humans. We use deep phenotyping in individuals with orofacial clefts and their family members, genetic association methods, and next generation sequencing to identify novel genetic risk factors and to understand fundamental questions of phenotypic heterogeneity, penetrance, and variable expressivity.
